Parts of Saddleworth could see as much as 10 inches of snowfall in just six hours.
The Met Office has put an amber weather warning in place that is expected to cause travel disruption across the Peak District and south Pennines tomorrow between 12pm and 6pm.
While Saddleworth sits just outside the warning area, as the crow flies Diggle is just three miles from Marsden, which is covered.
The Met Office said: "Snow is expected to develop during Thursday morning and become persistent and at times heavy by the afternoon before slowly easing through the evening.
"Across the warning area, 10 to 15cm of snow is expected quite widely but some places, particularly above 300 metres, may see 25cm of snow.
"Strong and gusty easterly winds may lead to some drifting in places."
According to forecasters, it is likely that residents in rural communities could become temporarily cut off, and power cuts may occur, while other services such as mobile phone coverage might be affected.
Advice has been issued by the Met Office for those who may become isolated due to snow, which includes keeping the thermostat set to the same temperature both during the day and at night, turning off electrical heaters and putting out the fire before going to bed.
They also advise residents should ensure their pets are safe by keeping them warm and comfortable, prevent pipes from freezing by opening kitchen and bathroom cabinet doors to allow warmer air to circulate around the plumbing, and to stay indoors, wrap up warm and close internal doors to keep the heat in.
Those who need support should call the British Red Cross on 0808 196 3651.
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