Dame Cressida Dick has left her role as the Metropolitan Police commissioner.
She has served as the Commissioner of Police of the Metropolis since 2017 after being selected by the Home Office to succeed Bernard Hogan-Howe.
Early reports suggest Mayor of London Sadiq Kahn asked her to step down.
Sadiq Khan issues statement amid Cressida Dick resignation from Met Police
Mayor of London Sadiq Khan, said: "Last week, I made clear to the Metropolitan Police Commissioner the scale of the change I believe is urgently required to rebuild the trust and confidence of Londoners in the Met and to root out the racism, sexism, homophobia, bullying, discrimination and misogyny that still exists.
"I am not satisfied with the Commissioner's response.
"On being informed of this, Dame Cressida Dick has said she will be standing aside. It's clear that the only way to start to deliver the scale of the change required is to have new leadership right at the top of the Metropolitan Police."
It comes after the commissioner told rogue officers to “get out now, otherwise we will find you” as she insisted she was still the right person for the job.
Dame Cressida Dick said she was “seething angry” about racist, misogynist and homophobic messages exchanged by officers.
Her comments came after a series of disturbing messages exchanged by a group of officers, primarily based at Charing Cross police station, were published by a watchdog last week.
Speaking to BBC Radio London on Thursday, she said she had boosted the force’s anti-corruption command in a bid to root out other officers with similar views.
She said: “I am seething angry about the whole thing. I’m very glad that the four individuals have left.
“There is no place in the Met for sexism or racism or homophobia, for abuse of trust or for bullying, and in the last few days I have gone out extremely strongly to my colleagues and told them enough is enough.
“This is a fantastic police service. It is hugely capable in so many ways, but its reputation has been tarnished by the awful things that you were hearing about there in relation to the impact team at Charing Cross and also, some other awful things have happened and come to light in the last several months.
“So I am absolutely determined that we will be getting out there and rooting out any further individuals.
“I’ve already said, if you have those attitudes or behaviours, get out now. Otherwise, we will find you and I have a whole new team which will be helping me root out individuals and, indeed, where there are dysfunctional or toxic teams, rooting those out too … But if we do have people who are like the four that left at Charing Cross, they’re not welcome in my Met.”
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